BASF Innovations

Photo, left: In addition to sugar production, sugarcane is being increasingly used as a raw material for ethanol – an important vehicle fuel in Brazil as well as a promising raw material for manufacturing plastics. Photo, right: A Brazilian farmer inspects a sugarcane plant for infestation and disease. (photo)

Image: Film-coated tablets covered with Kollicoat IR®

A tablet coating of many talents

Tablet coatings no longer need to include a separate plasticizer, thanks to the polymer Kollicoat IR®. It provides particularly effective protection for the active ingredients in film-coated pharmaceutical tablets and nutritional supplements, while also allowing for more efficient and resource-saving production methods.

Innovative polymer structure

Tablets with readily soluble coatings ensure rapid uptake in the body while protecting the drugs inside from light, oxygen and moisture. To keep the coating stable at room temperature and prevent it from becoming brittle, pharmaceutical manufacturers generally need to add a plasticizer. Over the tablet’s lifespan, this can seep from the coating to the inside and interfere with the active ingredients there. Kollicoat IR® is the first tablet coating that does not require a separate plasticizer. Its innovative polymer structure combines film-forming properties with plasticizing action, thus ruling out any damage to the drugs inside.

More efficient tablet production

The polymer’s special structure also greatly reduces viscosity, providing pharmaceutical manufacturers with further benefits in processing: The coating can be applied much more rapidly, creating a smoothly homogenous, crack-free surface that protects the ingredients from outside influences. The entire process results in savings of up to 60% in terms of water, energy and time.

Improved shelf life

Kollicoat IR® furthermore serves as an effective bonding agent, ensuring that the active ingredients cohere solidly. Because the polymer neither contains nor creates peroxides on contact with oxygen, oxygen-sensitive ingredients maintain their shelf life even over longer storage periods. This property, along with the substance’s extremely high cohesiveness, makes Kollicoat IR® unique in comparison with conventional binding agents and opens up new possibilities for pharmaceutical manufacturers, especially in formulations for such sensitive ingredients.